十七章填空-22章

更新时间：试题数量：购买人数：提供作者：

有效期：个月

章节介绍：共有个章节

收藏

我的练习

我的错题
(0道)

我的收藏
(0道)

我的斩题
(0道)

我的笔记
(0道)

专项练习

顺序练习 练习进度 0 / 0

随机练习 自定义设置练习量

模拟考试 仿真模拟

题型练习 按题型分类练习

易错题 精选高频易错题

学习资料 考试学习相关信息

搜索

题库预览

对于治疗指数(TI)小的药物在设计中应注意血药浓度的波动性,稳态血药浓度的峰谷比值,即剂型指数(DI)应大于TI。( )

生物半衰期很长的药物制成缓控释制剂增加在体内蓄积的可能性,但仍能延长作用时间和减少某些不良反应。( )

为了既能获得可靠的治疗效果,又不致产生毒副作用,必须在缓控释制剂的设计、试制、生产等环节避免或减少突释。( )

缓控释制剂主要有____和____两种。药物以____或____的形式均匀分散在各种载体材料中,则形成____缓控释制剂;药物被____在骨架内形成____缓控释制剂。

缓释、控释、迟释制剂所涉及的释药原理主要有____、____、____、____和____作用。

渗透泵片剂的释药速率决定于____和____。

大多数药物在胃肠道的运行时间是____,如在结肠有吸收,则可能使药物释放时间增至____。

设法延长药物在胃中的停留时间,使其在胃中缓慢释放,然后到达吸收部位的制剂有____、____和____。

缓控释制剂一般适用于半衰期短的药物(t₁/₂为2~8小时),相对生物利用度一般应在普通制剂的____范围内。若药物吸收部位主要在胃与小肠,宜设计每____服一次,若药物在结肠也有一定的吸收,则可考虑每____服一次。

缓控释制剂稳态时的血药浓度小于普通制剂。一般____的药物,可设计12小时服一次;____的药物,则可24小时服一次。若设计零级释放剂型,如渗透泵,____。

缓控释制剂主要利用一些高分子材料阻滞药物的释放,根据阻滞方式不同,阻滞剂分为____、____和____。骨架型缓释材料主要有____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、__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__、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、____、__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